REVIEW ARTICLE


Exploring the Role of Mesenchymal Stem Cells During Normothermic Organ Perfusion: A New Paradigm to Enhance Outcome Following Allograft Transplantation



Mohamed Morsy1, *, Mohammad Ayaz Hossain2, Atul Bagul3
1 Consultant Transplant Surgeon, University Hospitals of Leicester/Leicester General Hospital, Leicester, LE5 4PW, UK
2 Specialty Registrar in Organ transplantation, Cambridge University Hospital NHS Trust, Hills Rd, Cambridge, UK
3 Head of Transplantation Services and Consultant Endocrine and Transplant surgeon, Leicester General Hospital, Leicester, LE5 4PW, UK


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© 2018 Morsy et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Consultant Transplant Surgeon, University Hospitals of Leicester/Leicester General Hospital, Leicester, LE5 4PW, UK, E-mail: Mohamed.morsy@nhs.net


Abstract

Background:

Normothermic Machine Perfusion (NMP) has been established in the field of solid organ transplantation for both liver and kidney allografts. The ability to perfuse organs at body temperature enables viability assessment as well as optimisation prior to implantation.

Discussion:

A recent in vitro report of the use of Mesenchymal Stem Cells (MSCs) in the use of a normothermic lung perfusion circuit has raised the possibility of their use in solid organ transplantation. The aim of this short review is to outline the potential uses of bone marrow derived MSCs for their use in renal allograft ex vivo NMP. An overview is provided of current literature of NMP as well as theorised uses for MSCs.

Keywords: Mesenchymal stem cells, Normothermic perfusion, Transplantation, Outcomes, Allograft, EMP.